Faculty Advisor
Billiar, Kristen
Faculty Advisor
Rolle, Marsha W
Abstract
In chronic wound healing there is an over-production of myofibroblasts, resulting from the stiffness of the surrounding environment. Wound healing is studied in vitro using collagen gels and stiffness is often determined using destructive methods. A device was developed to determine stiffness non-destructively by using transverse loading methods to measure force and displacement. The device was validated by comparing results with literature on transverse loading. Collagen gels were tested to demonstrate repeatability and illustrate compatibility with relevant wound healing models.
Publisher
Worcester Polytechnic Institute
Date Accepted
April 2008
Major
Biomedical Engineering
Major
Technical, Scientific and Professional Communication
Project Type
Major Qualifying Project
Copyright Statement
All authors have granted to WPI a nonexclusive royalty-free license to distribute copies of the work, subject to other agreements. Copyright is held by the author or authors, with all rights reserved, unless otherwise noted.
Accessibility
Unrestricted
Advisor Department
Biomedical Engineering