Rolle, Marsha W
In chronic wound healing there is an over-production of myofibroblasts, resulting from the stiffness of the surrounding environment. Wound healing is studied in vitro using collagen gels and stiffness is often determined using destructive methods. A device was developed to determine stiffness non-destructively by using transverse loading methods to measure force and displacement. The device was validated by comparing results with literature on transverse loading. Collagen gels were tested to demonstrate repeatability and illustrate compatibility with relevant wound healing models.
Worcester Polytechnic Institute
Technical, Scientific and Professional Communication
Major Qualifying Project
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