Faculty Advisor

Billiar, Kristen

Faculty Advisor

Rolle, Marsha W

Abstract

In chronic wound healing there is an over-production of myofibroblasts, resulting from the stiffness of the surrounding environment. Wound healing is studied in vitro using collagen gels and stiffness is often determined using destructive methods. A device was developed to determine stiffness non-destructively by using transverse loading methods to measure force and displacement. The device was validated by comparing results with literature on transverse loading. Collagen gels were tested to demonstrate repeatability and illustrate compatibility with relevant wound healing models.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2008

Major

Biomedical Engineering

Major

Technical, Scientific and Professional Communication

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biomedical Engineering

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