Faculty Advisor

Brodeur, Drew R

Faculty Advisor

Heilman, Destin

Center

University of Massachusetts Medical Center

Abstract

A scheme was constructed for synthesizing a MRI contrast agent with both MPO sensing and SOD therapeutic ability. This contrast agent was designed by modifying a previously published paramagnetic SOD mimetic with therapeutic ability to contain a substrate group for MPO. This allows the contrast agent to accumulate in sites of high MPO concentration, increasing MRI signal intensity. The scheme relies on economic dipicolinic acid as a starting material for the functionalized ligand. The reaction intended to be utilized to attach the MPO substrate is an environmentally-friendly “click chemistry” reaction. Both synthetic building blocks for the click chemistry reaction were synthesized and characterized and a new, final scheme was devised in order to increase yield and convenience.

Publisher

Worcester Polytechnic Institute

Date Accepted

June 2013

Major

Chemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Project Center

University of Massachusetts Medical Center

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