Faculty Advisor

Heilman, Destin

Faculty Advisor

Vidali, Luis

Abstract

In Physcomitrella patens, actin-mediated trafficking and myosin XIa are essential for polarized growth. In other model organisms, the association between myosin and its cargo is mediated by Rab-GTPases. We cloned and purified wild type and mutants of moss myosin XIa that fail to complement an RNAi myosin XIa loss-of-polarity phenotype. Through binding assays, we identified RabA21 as having potential myosin XIa binding activity. The disruption of this interaction may be responsible for the lack of rescue of the phenotype.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2015

Major

Biology and Biotechnology

Major

Biochemistry

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Chemistry and Biochemistry

Advisor Department

Biology and Biotechnology

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