Faculty Advisor

Adams, David S.

Abstract

In primates, complement-coated invading microbes and immune complexes are efficiently removed from circulation by binding complement receptor-1 (CR1) on erythrocytes, a process known as immune-adherence clearance. This project examines the nature and functionality of complement binding to erythrocytes under normal and pathological conditions. The data identifies key factors associated with the complement-CR1 ligation pathway promoting membrane deformability, helping elucidate a greater understanding of this important, unique erythrocyte function.

Publisher

Worcester Polytechnic Institute

Date Accepted

April 2013

Major

Biology and Biotechnology

Project Type

Major Qualifying Project

Accessibility

Unrestricted

Advisor Department

Biology and Biotechnology

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